Da Huang Zhe Chong Wan
Rhubarb and Eupolyphaga Pill
- Category
- Formulas that Invigorate the Blood
- Ingredients
- 12 herbs
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What does Da Huang Zhe Chong Wan do?
Da Huang Zhe Chong Wan (Rhubarb and Eupolyphaga Pill) gradually breaks up severe, long-standing blood stasis — classically called “dry blood” (gan xue) — while nourishing the blood and yin that stasis of this severity has already damaged. It is a Jin Gui Yao Lue formula built around several insect- and worm-derived blood-breaking substances alongside Da Huang, combined as a pill rather than a strong decoction so that a deeply entrenched stasis can be worn down slowly in a patient who is often already depleted.
- Chief: Da Huang purges heat and breaks stasis, directing stagnant blood out through the bowels.
- Deputies (the “insect and worm” group): Tu Bie Chong (Eupolyphaga), Meng Chong (Tabanus/gadfly), Shui Zhi (Hirudo/leech), and Qi Cao (Holotrichia larva) are strong animal-derived blood-breakers, used together because chronic, deeply lodged stasis often does not respond fully to plant-based blood movers alone.
- Assistants: Tao Ren invigorates blood and moistens dryness; Gan Qi (processed lacquer resin) is a potent stasis-breaker included in small amount; Huang Qin clears the heat that chronic stasis generates; Xing Ren helps move qi downward and moistens, supporting the formula’s overall downward, purgative direction.
- Assistants (nourishing pair): Sheng Di Huang and Bai Shao nourish blood and yin, offsetting the drying, damaging potential of so many aggressive blood-breaking ingredients used together.
- Envoy: Gan Cao harmonizes the formula and moderates the toxicity and harshness of the stronger ingredients.
Source: Jin Gui Yao Lue; Bensky & Barolet, Formulas & Strategies (chief/deputy/assistant/envoy analysis). Traditional-use framing; not medical advice.
Indications
What is Da Huang Zhe Chong Wan used for?
Da Huang Zhe Chong Wan treats severe, chronic blood stasis with dryness and depletion — the Jin Gui Yao Lue’s “dry blood” (gan xue) pattern within one of the five taxations/consumptive-disease (xu lao) categories — marked by dry, rough, scaling skin and fixed abdominal masses in a generally emaciated, depleted patient.
- Skin and constitutional signs: dry, rough, scaly skin classically likened to fish scales, dark discoloration around the eyes, emaciation, and a generally malnourished appearance despite ongoing food intake.
- Abdominal masses: fixed, painful masses or lumps (zheng jia) in the abdomen from long-standing stasis.
- Gynecological presentation: amenorrhea in women, where stasis has blocked the Penetrating (Chong) and Conception (Ren) vessels.
- The classical paradox: despite describing a depleted, consumptive patient, the formula is built around strong purgative and blood-breaking herbs — appropriate here because the entrenched stasis itself, not simple deficiency, is what is preventing new blood from being generated.
Source: Jin Gui Yao Lue; Sacred Lotus sources & references (diagnostic profile); Bensky & Barolet, Formulas & Strategies. Traditional-use framing; not medical advice.
Ingredients
12 substances in Da Huang Zhe Chong Wan — each links to its full herb monograph.
Da Huang300 gPurgativesNo specimen photographTu Bie Chong30 gInvigorate Blood and Remove StagnationNo specimen photographGan Qi30 gInvigorate Blood and Remove StagnationNo specimen photographMeng Chong60 gInvigorate Blood and Remove StagnationNo specimen photographQi Cao60 gUncategorized Herbs
Shui Zhi60 gInvigorate Blood and Remove Stagnation
Tao Ren60 gInvigorate Blood and Remove Stagnation
Bai Shao120 gTonify Blood
Huang Qin60 gClear Heat and Dry Dampness
Sheng Di Huang300 gCool the Blood
Xing Ren60 gRelieve Coughing and Wheezing
Gan Cao90 gTonify QiPreparation & dosage
How is Da Huang Zhe Chong Wan prepared?
Da Huang Zhe Chong Wan is traditionally ground into a fine powder and formed into honey pills of about 3 g, taken one to three times daily with warm water or wine — a small, sustained dose consistent with its gradual-attack strategy. All twelve ingredients, including the several insect/worm substances, are combined into an even powder before being bound with honey. Some practitioners reduce the classical proportions and prepare a decoction instead when a stronger or faster effect is wanted, though this departs from the original slow-pill approach that the formula was specifically designed around.
Source: Sacred Lotus sources & references (preparation notes); Jin Gui Yao Lue; Bensky & Barolet, Formulas & Strategies.
Safety — read before use
What are the cautions for Da Huang Zhe Chong Wan?
Da Huang Zhe Chong Wan is strictly contraindicated in pregnancy — its combination of a strong purgative (Da Huang) with multiple potent, animal-derived blood-breaking ingredients carries a serious risk of miscarriage, and this caution appears consistently across the classical and modern formulary literature.
- Pregnancy: absolutely avoided; this is among the more strongly contraindicated formulas in the classical Chinese pharmacopeia for this reason.
- Gan Qi (processed lacquer resin): a potent, potentially irritant/toxic substance in classical Chinese pharmacology, included only in small, carefully processed amounts; not a substance for self-prescription.
- Animal-derived ingredients: Tu Bie Chong, Meng Chong, Shui Zhi, and Qi Cao are insect/arthropod-derived; those with relevant allergies, or who wish to avoid animal-derived medicinals, should be aware of the composition (noted here as reference information; our formula data is not modified).
- Not for general deficiency or ordinary amenorrhea without true dry-blood/stasis signs — the formula’s strength is intended for entrenched, severe stasis, not routine blood deficiency, and misuse can further deplete an already weak patient.
- Bleeding tendencies: as a strong blood-invigorating formula, caution is warranted in patients with a bleeding disorder or on anticoagulant therapy; professional guidance is advised.
Source: Jin Gui Yao Lue; Bensky & Barolet, Formulas & Strategies (pregnancy contraindication; ingredient cautions). Traditional-use framing; not medical advice.
Originally Appeared In:
- Essentials from the Golden Cabinet (Jin Gui Yao Lue)
Notes:
How does Da Huang Zhe Chong Wan differ from Gui Zhi Fu Ling Wan and Xue Fu Zhu Yu Tang?
All three are classical or well-known blood-stasis formulas, but they differ sharply in strength, ingredients, and who they are safe for.
- vs Gui Zhi Fu Ling Wan: also a Jin Gui Yao Lue blood-stasis pill for an abdominal mass, but built from gentle plant-based herbs (Gui Zhi, Fu Ling, Mu Dan Pi, Tao Ren, Bai Shao) without any insect/worm ingredients or strong purgatives — it is used cautiously even for a stable fetal mass in pregnancy, the opposite safety profile from Da Huang Zhe Chong Wan.
- vs Xue Fu Zhu Yu Tang: Wang Qing-ren’s later, Qing-dynasty formula treats blood stasis in the chest with an entirely plant-based, considerably gentler set of qi- and blood-moving herbs; it has broad modern use for general stasis patterns, whereas Da Huang Zhe Chong Wan’s animal-derived, purgative-driven approach is reserved for severe, entrenched “dry blood” that gentler formulas cannot reach.
- “Dry blood” (gan xue) as a category: this term describes stasis blood that has become so long-standing it can no longer nourish the tissues (hence the dry, scaling skin), distinguishing it from the more recent or milder stasis that other blood-invigorating formulas address.
Source: Jin Gui Yao Lue; Bensky & Barolet, Formulas & Strategies (comparative formula analysis).
Clinical Studies & Research:
Is there modern research on Da Huang Zhe Chong Wan?
Yes — under its pharmacology-literature name Dahuang Zhechong Wan/Pills, it has been studied clinically for chronic liver disease and, more recently, in preclinical aging-related mechanism studies. A randomized trial in 94 patients with chronic hepatitis B found that adding Dahuang Zhechong Wan to antiviral therapy (adefovir dipivoxil) over six months improved liver fibrosis markers and enzyme levels more than antiviral therapy alone (PMID 22715739). More recent preclinical work has explored broader mechanisms in rat models of aging: a D-galactose-induced liver-aging model improved via ROS-mediated PI3K/Akt/FoxO4 signaling (PMID 37381959), and a parallel renal-aging model showed improved kidney function and metabolomic changes involving the AMPK pathway (PMID 39041160). Earlier work also studied the formula’s anti-arterial-thrombosis effects (PMID 22734422).
Sources: PubMed 22715739; PubMed 37381959; PubMed 39041160; PubMed 22734422. Research context on blood-stasis-related mechanisms and chronic liver disease, not a treatment claim for any diagnosed condition.
Sources & References
Compiled and edited by Thomas Dehli, Founder & Editor, Sacred Lotus Updated
The information here is referenced from numerous sources — teachers, practitioners, class notes from Five Branches University, the books below, and the published research literature, with citations given as resolvable PubMed identifiers. Where sources disagree, I have flagged the discrepancies directly. If facts couldn't be verified, I have left them out. How we source our content.
Reference information for students and practitioners — not medical advice. Consult a qualified practitioner. Terms of use.
Chinese Formulas Books & References
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